Postdocs on dynamic Functional Connectivity analyses and modelling in Alzheimer’s disease

We are happy to announce two postdoc openings in the FunSy team, for computational research together with Dr. Demian Battaglia. The recruited postdocs will work as well in close collaboration with Dr. Romain Goutagny in Strasbourg and Dr. Viktor Jirsa at the Institute for Systems Neuroscience in Marseille. Both positions will focus on investigating theLire la suite “Postdocs on dynamic Functional Connectivity analyses and modelling in Alzheimer’s disease”

Two gamma bands? Or two gamma complex ensembles?

In our newest preprint on BioRxiv, in collaboration with Alessandro Torcini and Matteo di Volo, we revisit a classic theory about the existence of two different gamma rhythms in the hippocampus CA1. We first deconstruct this theory, showing its insufficiency to account for the haphazard diversity of hippocampal gamma. We however reconstruct and rescue theLire la suite “Two gamma bands? Or two gamma complex ensembles?”

Densely tied in space… but also for a sufficient time!

Functional interactions between brain regions or neurons have been described using features defined in network theory. For instance, the rich club phenomenon correspond to having high-degree nodes connected between them above chance-level. In our new Nature Physics paper we generalize this notion to dynamic networks. Indeed, in order for a certain spatial pattern in networkLire la suite “Densely tied in space… but also for a sufficient time!”

Graph-based features to capture the embodiment of adaptive behavior

The cerebellar cortex encodes sensorimotor adaptation during skilled locomotor behaviors, however the precise relationship between synaptic connectivity and behavior is unclear. In our recent Nature Communications paper (in collaboration with Philippe Isope’s group at INCI, Strasbourg), we studied synaptic connectivity between granule cells (GCs) and Purkinje cells (PCs) in murine acute cerebellar slices using photostimulationLire la suite “Graph-based features to capture the embodiment of adaptive behavior”

Toward virtual connectomes for data augmentation

Personalized information on anatomic connectivity (structural connectivity; SC) or coordinated resting state activation patterns (functional connectivity; FC) is a source of powerful neuromarkers to detect and track the development of neurodegenerative diseases. However, there are often “gaps” in the available information, with only SC (or FC) being known but not FC (or SC). In ourLire la suite “Toward virtual connectomes for data augmentation”

Effects of localized brain stimulation depend on dynamical state

Stimulation can be used to alter brain activity and is a therapeutic option for certain neu- rological conditions. However, predicting the distributed effects of local perturbations is difficult. Previous studies show that responses to stimulation depend on anatomical (or structural) coupling. In addition to structure, in our PLoS Computational Biology paper (in collaboration with DanielleLire la suite “Effects of localized brain stimulation depend on dynamical state”

The speed and geometry of resting state dynamic Functional Connectivity

We are happy announcing that a diptych of publications on resting dynamic Functional Connectivity is finally out on NeuroImage! Functional Connectivity (FC) measured on resting state fMRI is dynamic and continually reconfiguring. However these variations are not necessarily very large and discrete state transitions are difficult (or questionable) to identify. Here we introduce a newLire la suite “The speed and geometry of resting state dynamic Functional Connectivity”

Is human cortical connectome optimized for ignition?

The activity of the cortex in mammals constantly fluctuates in relation to cognitive tasks, but also during rest. The ability of brain regions to display ignition, a fast transition from low to high activity is central for the emergence of conscious perception and decision making. In our recently published paper in PLoS Computational Biology (inLire la suite “Is human cortical connectome optimized for ignition?”

Computing hubs and states in the hippocampus?

In dominant views, a neuron becomes a functional hub because of its special position within a circuit. In our recently accepted paper on Science Advances, we find experimental evidence supporting a much more democratic view in which almost a majority of recorded single units could serve as hub at least for some time and forLire la suite “Computing hubs and states in the hippocampus?”

Communication through transient and stochastic coherence

Inter-regional oscillatory coherence has been proposed as a mechanism for modulating communication. However oscillations in vivo are transient and fluctuate in time, frequency and phase. In out Nature Neuroscience paper we show that, despite their irregular and stochastic-like properties, oscillatory burst can still subserve flexible and selective routing of information. To reach this conclusion weLire la suite “Communication through transient and stochastic coherence”