Two gamma bands? Or two gamma complex ensembles?

In our newest preprint on BioRxiv, in collaboration with Alessandro Torcini and Matteo di Volo, we revisit a classic theory about the existence of two different gamma rhythms in the hippocampus CA1. We first deconstruct this theory, showing its insufficiency to account for the haphazard diversity of hippocampal gamma. We however reconstruct and rescue theLire la suite “Two gamma bands? Or two gamma complex ensembles?”

AD before plaques

Alzheimer’s disease (AD) is a neurodegenerative pathology commonly characterized by a progressive and irreversible deterioration of cognitive functions, especially memory. Although the etiology of AD remains unknown, a consensus has emerged on the amyloid hypothesis, which posits that increased production of soluble amyloid b (Ab) peptide induces neuronal network dysfunctions and cognitive deficits. In ourLire la suite “AD before plaques”

Theta-gamma coupling as “Eureka”?

Spatial reference memory in rodents represents a unique opportunity to study brain mechanisms responsible for encoding, storage and retrieval of a memory. Even though its reliance on hippocampal networks has long been established, the precise computations performed by different hippocampal subfields during spatial learning are still not clear. In our Cerebral Cortex paper, to studyLire la suite “Theta-gamma coupling as “Eureka”?”

Hippocampal theta without pacemakers

Hippocampal theta rhythm is crucial for spatial memory and is thought to be generated by extrinsic inputs. In our Nature Neuroscience paper, though, we show that, using a complete rat hippocampus in vitro, several intrinsic, atropine-resistant theta generators can be found directly in CA1. These oscillators were organized along the septotemporal axis and arose independentlyLire la suite “Hippocampal theta without pacemakers”