The claustrum is one of the brain’s most intriguing structures: a thin, deeply located sheet of neurons, densely and reciprocally connected with many cortical areas. Because of this connectivity, it has often been discussed as a possible hub for attention, integration, or even consciousness. In this review, in collaboration with the group of Dr. JesseLire la suite « The claustrum and synchronized brain states: a small structure with a large-scale role »
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Arkypallidal neurons in the external globus pallidus can mediate inhibitory control by altering competition in the striatum
Stopping an action at the right moment is a fundamental form of cognitive control. Whether avoiding an obstacle, cancelling a planned movement, or adapting to a sudden change in the environment, the brain must sometimes rapidly suppress an action that is already being prepared. This process, known as reactive inhibitory control, has classically been attributedLire la suite « Arkypallidal neurons in the external globus pallidus can mediate inhibitory control by altering competition in the striatum »
Cortical cross-frequency coupling alterations as a novel biomarker of ALS?
We have published a new article in collaboration avec Véronique Marchand-Pauvert (Paris), Sabine Liebscher (Munich/Cologne) and Caroline Rouaux (Strasbourg). In this Science Translational Medicine paper we show that the cross-frequency coupling analyses we have used in previous papers can serve as a promising biomarker for Amyotrophic lateral sclerosis (ALS). ALS is a devastating neurodegenerative disease,Lire la suite « Cortical cross-frequency coupling alterations as a novel biomarker of ALS? »
Hippocampal gamma oscillatory complexity is not noise but reflects behavior and learning
Our FunSy paper on gamma oscillatory complexity in hippocampus is out in Nature Comms! The hippocampus and entorhinal cortex exhibit rich oscillatory patterns critical for cognitive functions. In the hippocampal region CA1, specific gamma-frequency oscillations, timed at different phases of the ongoing theta rhythm, are hypothesized to facilitate the integration of information from varied sources andLire la suite « Hippocampal gamma oscillatory complexity is not noise but reflects behavior and learning »
Subject-specific maximum entropy model of resting state fMRI shows diagnostically distinct patterns of energy state distributions
Existing neuroimaging studies of psychotic and mood disorders have reported regional brain activation differences (first-order properties) and alterations in functional connectivity based on pairwise correlations in activation (second-order properties). In this preprint, in collaboration with Jonathan Rubin, Konasal Prasad et al. (Pittsburgh, PA), we use a generalized Ising model, also called a pairwise maximum entropyLire la suite « Subject-specific maximum entropy model of resting state fMRI shows diagnostically distinct patterns of energy state distributions »
Brain-state-dependent constraints on claustrocortical communication and function
Our new paper in collaboration with Jesse Jackson (Edmonton) is out ! Neural activity in the claustrum has been associated with a range of vigilance states, yet the activity patterns and efficacy of synaptic communication of identified claustrum neurons have not been thoroughly determined. Here, we show that claustrum neurons projecting to the retrosplenial cortex are most active during synchronized cortical statesLire la suite « Brain-state-dependent constraints on claustrocortical communication and function »
Different Faces of Medial Beta-Band Activity Reflect Distinct Visuomotor Feedback Signals
Beta-band activity reflects neural processes well beyond sensorimotor functions, including cognition and motivation. In this Journal of Neuroscience article in collaboration with Nicola Malfait (Marseille), by disentangling alternative spatio-temporal-spectral patterns of possible beta-oscillatory activity, we reconcile a seemingly discrepant literature. First, high-beta power in the medial frontal cortex showed opposite modulations separated in time inLire la suite « Different Faces of Medial Beta-Band Activity Reflect Distinct Visuomotor Feedback Signals »
Prefrontal–striatal projection neurons support the maintenance of working memory
Working memory is the ability to keep information available for a short period of time in order to guide behavior. It is essential for flexible cognition, but the circuit mechanisms that allow prefrontal networks to maintain information across a delay remain incompletely understood. Together with Fritjof Helmchen’s group at the University of Zurich, we investigatedLire la suite « Prefrontal–striatal projection neurons support the maintenance of working memory »
Competing neural representations of choice shape evidence accumulation in humans
Making adaptive choices in dynamic environments requires flexible decision policies. Previously, we showed how shifts in outcome contingency change the evidence accumulation process that determines decision policies. In this eLife article we published in collaboration with Jonathan Rubin, Timothy Verstynen (Pittsburgh, PA) et al, we used in silico experiments to generate predictions and show howLire la suite « Competing neural representations of choice shape evidence accumulation in humans »
Perturbed Information Processing Complexity in Experimental Epilepsy
Usually we think that pathologies, as epilepsy, are associated to disruptions of the neural circuit mediating function. These disruptions certainly exist and are related e.g. to seizure events, which are rare and transient events. On the contrary, comorbidities, such as cognitive deficits, which often accompany epilepsies, constitute a basal state. This suggests that neural dynamics,Lire la suite « Perturbed Information Processing Complexity in Experimental Epilepsy »