The excess of 15-30 Hz (β-band) oscillations in the basal ganglia is one of the key signatures of Parkinson’s disease (PD). The STN-GPe network is integral to generation and modulation of β band oscillations in basal ganglia. However, the role of changes in the firing rates and spike bursting of STN and GPe neurons in shaping theseLire la suite « Uncoupling the roles of firing rate and spike bursts in shaping the gpe-stn beta band oscillations. »
Archives de l’étiquette : FunSy
High-density multi-fiber photometry opens a window onto brain-wide circuit dynamics
Understanding behavior requires measuring how many brain regions interact at the same time. Yet most optical techniques historically faced a trade-off: they could record neural activity with good cellular or regional specificity, but only from a limited number of sites. This made it difficult to follow how distributed brain circuits coordinate activity during behavior. InLire la suite « High-density multi-fiber photometry opens a window onto brain-wide circuit dynamics »
Computing hubs and states in the hippocampus?
In dominant views, a neuron becomes a functional hub because of its special position within a circuit. In our recently accepted paper on Science Advances, we find experimental evidence supporting a much more democratic view in which almost a majority of recorded single units could serve as hub at least for some time and forLire la suite « Computing hubs and states in the hippocampus? »
Homologous basal ganglia network models in physiological and parkinsonian conditions
The classical model of basal ganglia has been refined in recent years with discoveries of subpopulations within a nucleus and previously unknown projections. One such discovery is the presence of subpopulations of arkypallidal and prototypical neurons in external globus pallidus, which was previously considered to be a primarily homogeneous nucleus. Developing a computational model ofLire la suite « Homologous basal ganglia network models in physiological and parkinsonian conditions »
AD before plaques
Alzheimer’s disease (AD) is a neurodegenerative pathology commonly characterized by a progressive and irreversible deterioration of cognitive functions, especially memory. Although the etiology of AD remains unknown, a consensus has emerged on the amyloid hypothesis, which posits that increased production of soluble amyloid b (Ab) peptide induces neuronal network dysfunctions and cognitive deficits. In ourLire la suite « AD before plaques »
Theta-gamma coupling as « Eureka »?
Spatial reference memory in rodents represents a unique opportunity to study brain mechanisms responsible for encoding, storage and retrieval of a memory. Even though its reliance on hippocampal networks has long been established, the precise computations performed by different hippocampal subfields during spatial learning are still not clear. In our Cerebral Cortex paper, to studyLire la suite « Theta-gamma coupling as « Eureka »? »