We are happy announcing that a diptych of publications on resting dynamic Functional Connectivity is finally out on NeuroImage! Functional Connectivity (FC) measured on resting state fMRI is dynamic and continually reconfiguring. However these variations are not necessarily very large and discrete state transitions are difficult (or questionable) to identify. Here we introduce a newLire la suite « The speed and geometry of resting state dynamic Functional Connectivity »
Archives de la catégorie : Publication
Is human cortical connectome optimized for ignition?
The activity of the cortex in mammals constantly fluctuates in relation to cognitive tasks, but also during rest. The ability of brain regions to display ignition, a fast transition from low to high activity is central for the emergence of conscious perception and decision making. In our recently published paper in PLoS Computational Biology (inLire la suite « Is human cortical connectome optimized for ignition? »
Uncoupling the roles of firing rate and spike bursts in shaping the gpe-stn beta band oscillations.
The excess of 15-30 Hz (β-band) oscillations in the basal ganglia is one of the key signatures of Parkinson’s disease (PD). The STN-GPe network is integral to generation and modulation of β band oscillations in basal ganglia. However, the role of changes in the firing rates and spike bursting of STN and GPe neurons in shaping theseLire la suite « Uncoupling the roles of firing rate and spike bursts in shaping the gpe-stn beta band oscillations. »
High-density multi-fiber photometry opens a window onto brain-wide circuit dynamics
Understanding behavior requires measuring how many brain regions interact at the same time. Yet most optical techniques historically faced a trade-off: they could record neural activity with good cellular or regional specificity, but only from a limited number of sites. This made it difficult to follow how distributed brain circuits coordinate activity during behavior. InLire la suite « High-density multi-fiber photometry opens a window onto brain-wide circuit dynamics »
Computing hubs and states in the hippocampus?
In dominant views, a neuron becomes a functional hub because of its special position within a circuit. In our recently accepted paper on Science Advances, we find experimental evidence supporting a much more democratic view in which almost a majority of recorded single units could serve as hub at least for some time and forLire la suite « Computing hubs and states in the hippocampus? »
Homologous basal ganglia network models in physiological and parkinsonian conditions
The classical model of basal ganglia has been refined in recent years with discoveries of subpopulations within a nucleus and previously unknown projections. One such discovery is the presence of subpopulations of arkypallidal and prototypical neurons in external globus pallidus, which was previously considered to be a primarily homogeneous nucleus. Developing a computational model ofLire la suite « Homologous basal ganglia network models in physiological and parkinsonian conditions »
Communication through transient and stochastic coherence
Inter-regional oscillatory coherence has been proposed as a mechanism for modulating communication. However oscillations in vivo are transient and fluctuate in time, frequency and phase. In out Nature Neuroscience paper we show that, despite their irregular and stochastic-like properties, oscillatory burst can still subserve flexible and selective routing of information. To reach this conclusion weLire la suite « Communication through transient and stochastic coherence »
AD before plaques
Alzheimer’s disease (AD) is a neurodegenerative pathology commonly characterized by a progressive and irreversible deterioration of cognitive functions, especially memory. Although the etiology of AD remains unknown, a consensus has emerged on the amyloid hypothesis, which posits that increased production of soluble amyloid b (Ab) peptide induces neuronal network dysfunctions and cognitive deficits. In ourLire la suite « AD before plaques »
Attentional modulation of non-tuned tuning curves
Tuning curves are the functions that relate the responses of sensory neurons to various values within one continuous stimulus dimension (such as the orientation of a bar in the visual domain or the frequency of a tone in the auditory domain). They are commonly determined by fitting a bell-shaped curve to the measured responses. However,Lire la suite « Attentional modulation of non-tuned tuning curves »
Theta-gamma coupling as « Eureka »?
Spatial reference memory in rodents represents a unique opportunity to study brain mechanisms responsible for encoding, storage and retrieval of a memory. Even though its reliance on hippocampal networks has long been established, the precise computations performed by different hippocampal subfields during spatial learning are still not clear. In our Cerebral Cortex paper, to studyLire la suite « Theta-gamma coupling as « Eureka »? »