Archives de l’étiquette : jyotika

The excess of 15-30 Hz (β-band) oscillations in the basal ganglia is one of the key signatures of Parkinson’s disease (PD). The STN-GPe network is integral to generation and modulation of β band oscillations in basal ganglia. However, the role of changes in the firing rates and spike bursting of STN and GPe neurons in shaping theseLire la suite « Uncoupling the roles of firing rate and spike bursts in shaping the gpe-stn beta band oscillations. »

The classical model of basal ganglia has been refined in recent years with discoveries of subpopulations within a nucleus and previously unknown projections. One such discovery is the presence of subpopulations of arkypallidal and prototypical neurons in external globus pallidus, which was previously considered to be a primarily homogeneous nucleus. Developing a computational model ofLire la suite « Homologous basal ganglia network models in physiological and parkinsonian conditions »